Schizophrenia is characterized by positive symptoms (e.g., hallucination, delusions, disorganized thinking), negative symptoms (e.g., blunted affect, avolition, social withdrawal), and general psychopathology 5. Rhythmic brain stimulation, such as transcranial alternating current stimulation (tACS), transcranial magnetic stimulation (TMS), and deep brain stimulation (DBS), has been employed to restore physiological brain oscillations and thereby treat symptoms in patients 2, 3, 4. Considering existing research of 10Hz tACS as a treatment for major depressive disorder, our study demonstrates its transdiagnostic potential for treating depression.Īlterations in brain oscillations and the temporal coordination of neural activity between brain regions have been associated with a wide range of psychiatric disorders 1. ![]() Successful target engagement reduced depression and other general psychopathology symptoms, but not auditory hallucinations. Daily 10 Hz-tACS increased alpha power and altered alpha-band functional connectivity. Importantly, changes in brain functional connectivity significantly correlated with symptom improvement ( p < 0.05). tACS treatment increased alpha power in the target region ( p < 0.05), increased the frequency of peak global functional connectivity towards 10 Hz ( p < 0.05), and reduced left-right frontal functional connectivity ( p < 0.005). tACS treatment reduced general psychopathology ( p < 0.05, Cohen’s d = −0.690), especially depression ( p < 0.005, Cohen’s d = −0.806), but not auditory hallucinations. Patients were randomized to receive tACS or sham for five consecutive days during the treatment week (40 min/day), followed by a maintenance period, during which participants received weekly tACS (40 min/visit) or sham. ![]() 10-Hz tACS was administered in phase at the dorsolateral prefrontal cortex and the temporoparietal junction with a return current at Cz. We conducted a double-blind, randomized, placebo-controlled pilot clinical trial to examine the efficacy of 10-Hz tACS in treating auditory hallucinations in people with schizophrenia. Transcranial alternating current stimulation (tACS) at the alpha frequency was shown to enhance alpha oscillations in people with schizophrenia and may thus be a network-based treatment for auditory hallucinations. Reduced alpha oscillations may fail to censor spurious endogenous activity, leading to auditory hallucinations. Alpha oscillations are associated with top-down inhibition. People with schizophrenia exhibit reduced alpha oscillations and frontotemporal coordination of brain activity.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |